Issue 29, 2023

Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues

Abstract

Peptide and protein selective modification at tyrosine residues has become an exploding field of research as tyrosine constitutes a robust alternative to lysine and cysteine-targeted traditional peptide/protein modification protocols. This review offers a comprehensive summary of the latest advances in tyrosine-selective cleavage, functionalization, and conjugation of peptides and proteins from the past three years. This updated overview complements the extensive body of work on site-selective modification of peptides and proteins, which holds significant relevance across various disciplines, including chemical, biological, medical, and material sciences.

Graphical abstract: Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues

Article information

Article type
Review Article
Submitted
19 may 2023
Accepted
26 iyn 2023
First published
27 iyn 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2023,14, 7782-7817

Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues

S. Zhang, L. M. De Leon Rodriguez, F. F. Li and M. A. Brimble, Chem. Sci., 2023, 14, 7782 DOI: 10.1039/D3SC02543H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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