Issue 28, 2023

Site-selective carbonylation of arenes via C(sp2)–H thianthrenation: direct access to 1,2-diarylethanones

Abstract

Herein, a new reaction for the site-selective carbonylation of arenes via C(sp2)–H thianthrenation under mild conditions has been developed. With low loadings of palladium catalysts, various desired 1,2-diarylethanones are produced in good yields. This strategy also enables the late-stage modification of complex molecules, which was previously challenging with similar carbonylative Negishi-type reactions.

Graphical abstract: Site-selective carbonylation of arenes via C(sp2)–H thianthrenation: direct access to 1,2-diarylethanones

Supplementary files

Article information

Article type
Edge Article
Submitted
11 may 2023
Accepted
06 iyn 2023
First published
16 iyn 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2023,14, 7637-7641

Site-selective carbonylation of arenes via C(sp2)–H thianthrenation: direct access to 1,2-diarylethanones

J. Zhang, L. Wang, Z. Bao and X. Wu, Chem. Sci., 2023, 14, 7637 DOI: 10.1039/D3SC02402D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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