Issue 5, 2023

Scavenging neurotoxic aldehydes using lysine carbon dots

Abstract

Reactive aldehydes generated in cells and tissues are associated with adverse physiological effects. Dihydroxyphenylacetaldehyde (DOPAL), the biogenic aldehyde enzymatically produced from dopamine, is cytotoxic, generates reactive oxygen species, and triggers aggregation of proteins such as α-synuclein implicated in Parkinson's disease. Here, we demonstrate that carbon dots (C-dots) prepared from lysine as the carbonaceous precursor bind DOPAL molecules through interactions between the aldehyde units and amine residues on the C-dot surface. A set of biophysical and in vitro experiments attests to attenuation of the adverse biological activity of DOPAL. In particular, we show that the lysine-C-dots inhibit DOPAL-induced α-synuclein oligomerization and cytotoxicity. This work underlines the potential of lysine-C-dots as an effective therapeutic vehicle for aldehyde scavenging.

Graphical abstract: Scavenging neurotoxic aldehydes using lysine carbon dots

Supplementary files

Article information

Article type
Paper
Submitted
13 noy 2022
Accepted
17 yan 2023
First published
19 yan 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2023,5, 1356-1367

Scavenging neurotoxic aldehydes using lysine carbon dots

D. N. Bloch, M. Sandre, S. Ben Zichri, A. Masato, S. Kolusheva, L. Bubacco and R. Jelinek, Nanoscale Adv., 2023, 5, 1356 DOI: 10.1039/D2NA00804A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements