Issue 10, 2023

Flow cytometric printing of double emulsions into open droplet arrays

Abstract

Delivery of double emulsions in air is crucial for their applications in mass spectrometry, bioanalytics, and material synthesis. However, while methods have been developed to generate double emulsions in air, controlled printing of double emulsion droplets has not been achieved yet. In this paper, we present an approach for in-air printing of double emulsions on demand. Our approach pre-encapsulates reagents in an emulsion that is reinjected into the device, and generates double emulsions in a microfluidic printhead with spatially patterned wettability. Our device allows sorting of ejected double emulsion droplets in real-time, allowing deterministic printing of each droplet to be selected with the desired inner cores. Our method provides a general platform for building printed double emulsion droplet arrays of defined composition at scale.

Graphical abstract: Flow cytometric printing of double emulsions into open droplet arrays

Supplementary files

Article information

Article type
Paper
Submitted
22 fev 2023
Accepted
11 apr 2023
First published
12 apr 2023

Lab Chip, 2023,23, 2371-2377

Flow cytometric printing of double emulsions into open droplet arrays

P. Zhang, L. Xu, H. Chen and A. R. Abate, Lab Chip, 2023, 23, 2371 DOI: 10.1039/D3LC00151B

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