Issue 17, 2023

From screening to the hectogram scale: sustainable electrochemical synthesis of mefenpyr-diethyl

Abstract

To demonstrate the technical application potential of electrochemical reactions, we developed a synthetic method to access the commercially available herbicide safener mefenpyr-diethyl. In a simple undivided electrolysis cell with non-hazardous aqueous sodium iodide as supporting electrolyte and mediator, the target compound was synthesized via the (E)- or (Z)-hydrazone. Environmentally benign solvents or solvent-free conditions ensure a sustainable process and excellent recycling of the excess reagents. Finally, scale-up to the hectogram scale was performed with good to excellent yield.

Graphical abstract: From screening to the hectogram scale: sustainable electrochemical synthesis of mefenpyr-diethyl

Supplementary files

Article information

Article type
Communication
Submitted
15 iyn 2023
Accepted
27 iyl 2023
First published
01 avq 2023

Green Chem., 2023,25, 6623-6628

From screening to the hectogram scale: sustainable electrochemical synthesis of mefenpyr-diethyl

M. Linden, S. Hofmann, F. N. Weber, R. M. Bär, S. J. Kaldas, M. J. Ford and S. R. Waldvogel, Green Chem., 2023, 25, 6623 DOI: 10.1039/D3GC02118A

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