Issue 12, 2023

The effect of size, shape, coating and functionalization on nuclear relaxation properties in iron oxide core–shell nanoparticles: a brief review of the situation

Abstract

In this perspective article, we present a short selection of some of the most significant case studies on magnetic nanoparticles for potential applications in nanomedicine, mainly magnetic resonance. For almost 10 years, our research activity focused on the comprehension of the physical mechanisms on the basis of the nuclear relaxation of magnetic nanoparticles in the presence of magnetic fields; taking advantage of the insights gathered over this time span, we report on the dependence of the relaxation behaviour on the chemico-physical properties of magnetic nanoparticles and discuss them in full detail. In particular, a critical review is carried out on the correlations between their efficiency as contrast agents in magnetic resonance imaging and the magnetic core of magnetic nanoparticles (mainly iron oxides), their size and shape, and the coating and solvent used for making them biocompatible and well dispersible in physiological media. Finally, the heuristic model proposed by Roch and coworkers is presented, as it was extensively adopted to describe most of the experimental data sets. The large amount of data analyzed allowed us to highlight both the advantages and limitations of the model.

Graphical abstract: The effect of size, shape, coating and functionalization on nuclear relaxation properties in iron oxide core–shell nanoparticles: a brief review of the situation

Article information

Article type
Perspective
Submitted
18 okt 2022
Accepted
17 fev 2023
First published
20 fev 2023
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2023,52, 3551-3562

The effect of size, shape, coating and functionalization on nuclear relaxation properties in iron oxide core–shell nanoparticles: a brief review of the situation

P. Arosio, F. Orsini, F. Brero, M. Mariani, C. Innocenti, C. Sangregorio and A. Lascialfari, Dalton Trans., 2023, 52, 3551 DOI: 10.1039/D2DT03387A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements