Issue 46, 2023

Recent progress in metal complexes functionalized nanomaterials for photodynamic therapy

Abstract

Metal complexes have shown promise as photosensitizers for cancer diagnosis and therapeutics. However, the vast majority of metal photosensitizers are not ideal and associated with several limitations including pharmacokinetic limitations, off-target toxicity, fast systemic clearance, poor membrane permeability, and hypoxic tumour microenvironments. Metal complex functionalized nanomaterials have the potential to construct multifunctional systems, which not only overcome the above defects of metal complexes but are also conducive to modulating the tumour microenvironment (TME) and employing combination therapies to boost photodynamic therapy (PDT) efficacy. In this review, we first introduce the current challenges of photodynamic therapy and summarize the recent research strategies (such as metal coordination bonds, self-assembly, π–π stacking, physisorption, and so on) used for preparing metal complexes functionalized nanomaterials in the application of PDT.

Graphical abstract: Recent progress in metal complexes functionalized nanomaterials for photodynamic therapy

Article information

Article type
Highlight
Submitted
20 mar 2023
Accepted
02 may 2023
First published
03 may 2023

Chem. Commun., 2023,59, 6956-6968

Recent progress in metal complexes functionalized nanomaterials for photodynamic therapy

F. Wei, Z. Chen, X. Shen, L. Ji and H. Chao, Chem. Commun., 2023, 59, 6956 DOI: 10.1039/D3CC01355C

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