Issue 31, 2023

Enantioselective cyanation of propargylic C–H bonds via cooperative photoredox and copper catalysis

Abstract

Herein, we report an enantioselective cyanation of propargylic C–H bonds by combining photoredox catalysis with a copper-catalyzed radical relay in which the propargylic radical was generated by an intramolecular 1,5-HAT process. This reaction provides easy access to optically pure propargyl nitrile compounds under mild conditions.

Graphical abstract: Enantioselective cyanation of propargylic C–H bonds via cooperative photoredox and copper catalysis

Supplementary files

Article information

Article type
Communication
Submitted
29 yan 2023
Accepted
20 mar 2023
First published
21 mar 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 4656-4659

Enantioselective cyanation of propargylic C–H bonds via cooperative photoredox and copper catalysis

Y. Deng, R. Lu, P. Chen and G. Liu, Chem. Commun., 2023, 59, 4656 DOI: 10.1039/D3CC00410D

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