Issue 28, 2023

Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs

Abstract

Two photosensitizers (CCOH and CCN) were designed and synthesized by introducing coumarin into the curcumin (CUR) structure. Compared with CUR, more reactive oxygen species (ROS) were generated by CCOH and CCN in type I and II synergy upon light irradiation. Cell experiments indicated that CCN with an excellent LD-targeting effect could be used to monitor the changes in the morphology and number of LDs in tumor cells during PDT.

Graphical abstract: Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs

Supplementary files

Article information

Article type
Communication
Submitted
26 dek 2022
Accepted
09 mar 2023
First published
20 mar 2023

Chem. Commun., 2023,59, 4181-4184

Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs

X. Li, W. Liu, X. Zheng, M. Jiang, Y. Guo, J. Sha, J. Wu, H. Ren, H. Gao, S. Wang and P. Wang, Chem. Commun., 2023, 59, 4181 DOI: 10.1039/D2CC07025A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements