Issue 9, 2023

Enantioselective reductive allylic alkylation enabled by dual photoredox/palladium catalysis

Abstract

A dual photoredox/palladium catalyzed regio- and enantioselective reductive cross-coupling of allylic acetates with tertiary/secondary alkyl bromides has been achieved, and Hantzsch ester is used as a homogeneous organic reductant. This straightforward protocol enables the stereoselective construction of C(sp3)–C(sp3) bonds under mild reaction conditions. Mechanistic studies suggest that this reaction involves radical pathways and a chiral Pd complex enables the control of the regio- and enantioselectivities.

Graphical abstract: Enantioselective reductive allylic alkylation enabled by dual photoredox/palladium catalysis

Supplementary files

Article information

Article type
Communication
Submitted
09 dek 2022
Accepted
03 yan 2023
First published
03 yan 2023

Chem. Commun., 2023,59, 1153-1156

Enantioselective reductive allylic alkylation enabled by dual photoredox/palladium catalysis

S. Tang, H. Zhang and S. Yu, Chem. Commun., 2023, 59, 1153 DOI: 10.1039/D2CC06705F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements