Issue 8, 2023

An anti-glioblastoma gold(i)–NHC complex distorts mitochondrial morphology and bioenergetics to induce tumor growth inhibition

Abstract

Glioblastoma multiforme (GBM) is the most lethal brain cancer subtype, often advanced by the time of initial diagnosis. Existing treatment modalities including surgery, chemotherapy and radiation have been stymied by recurrence, metastasis, drug resistance and brain targetability. Here, we report a geometrically distinct Au(I) complex ligated by N^N-bidentate ligands and supported by a N-heterocyclic ligand that modulates mitochondrial morphology to inhibit GBM in vitro and in vivo. This work benefits from the facile preparation of anti-GBM Au(I)-NHC complexes.

Graphical abstract: An anti-glioblastoma gold(i)–NHC complex distorts mitochondrial morphology and bioenergetics to induce tumor growth inhibition

Supplementary files

Article information

Article type
Paper
Submitted
08 apr 2023
Accepted
19 may 2023
First published
25 may 2023
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2023,4, 592-599

An anti-glioblastoma gold(I)–NHC complex distorts mitochondrial morphology and bioenergetics to induce tumor growth inhibition

C. E. Greif, R. T. Mertens, G. Berger, S. Parkin and S. G. Awuah, RSC Chem. Biol., 2023, 4, 592 DOI: 10.1039/D3CB00051F

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