Issue 19, 2023

Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment

Abstract

The emergence of nanocarriers has greatly improved the therapeutic efficacy of chemotherapeutic drugs. As emerging nanocarriers, covalent organic frameworks (COFs) have been increasingly used in biomedicine in recent years. However, due to their inherent chemical stability, existing COF nanocarriers hardly undergo in vivo degradation, which brings potential safety hazards to further applications. In this work, we introduce the azo bond into COFs. When the nanocarrier enters the cell, ˙OH generated by the coordinated Fe response to the H2O2 in the cell will break the azo bond and cause the degradation of the framework structure, accelerating the release of internally loaded DOX to effectively realize tumor treatment. We verified the degradation ability of the materials by constructing model compounds, in vitro drug release, MTT assay and antitumor experiments. Compared with the control groups, the degradable COF accelerates the release of DOX and shows a stronger killing effect on 4T1 cells. Serum biochemical analysis and H&E sections of organs show good biocompatibility for both COFs and degradation products. This work provides a new idea for the design of biodegradable COFs in vivo, and greatly explores the potential application of COF materials in the biomedical field.

Graphical abstract: Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment

Supplementary files

Article information

Article type
Paper
Submitted
29 iyn 2023
Accepted
22 iyl 2023
First published
31 iyl 2023

Biomater. Sci., 2023,11, 6524-6536

Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment

T. Li, D. Wang, Z. Guo, L. Lin, M. Meng, C. Liu, K. Hao, X. Pang, H. Tian and X. Chen, Biomater. Sci., 2023, 11, 6524 DOI: 10.1039/D3BM01088K

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