Issue 16, 2023

Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

Abstract

Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to their capability to bypass the skin's stratum corneum (SC) barrier with minimal invasiveness. These carriers can achieve the targeted intradermal delivery of drugs and vaccines and improve their transdermal delivery level. As a nontoxic FDA-approved copolymer, polylactic glycolic acid (PLGA) has good biocompatibility and biodegradability. Currently, PLGA-based MNs have a noticeable tendency to be utilized as a delivery system. This study focuses on the most recent advances in PLGA-based MNs. Both PLGA nanoparticle-based MNs and PLGA matrix-based MNs, created for the delivery of vaccines, drugs, proteins and other therapeutic agents, are discussed. The paper also discusses the various types of MNs and their potential applications. Finally, the prospects and challenges of PLGA-based MNs are reviewed.

Graphical abstract: Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

  • This article is part of the themed collection: Microneedles

Article information

Article type
Review Article
Submitted
09 may 2023
Accepted
07 iyn 2023
First published
13 iyn 2023

Biomater. Sci., 2023,11, 5390-5409

Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

A. Malek-Khatabi, M. Sadat Razavi, A. Abdollahi, M. Rahimzadeghan, F. Moammeri, M. Sheikhi, M. Tavakoli, M. Rad-Malekshahi and Z. Faraji Rad, Biomater. Sci., 2023, 11, 5390 DOI: 10.1039/D3BM00795B

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