Issue 5, 2023

Expanding opportunities to engineer mucosal vaccination with biomaterials

Abstract

Mucosal vaccines are receiving increasing interest both for protecting against infectious diseases and for inducing therapeutic immune responses to treat non-infectious diseases. However, the mucosal barriers of the lungs, gastrointestinal tract, genitourinary tract, nasal, and oral tissues each present unique challenges for constructing efficacious vaccines. Vaccination through each of these mucosae requires transport through the mucus and across specialized epithelia to reach tissue-specific immune cells and lymphoid structures, necessitating finely tuned and multifunctional strategies. Serving as inspiration for mucosal vaccine design, pathogens have evolved elaborate, diverse, and multipronged approaches to penetrate and infect mucosae. This review is focused on biomaterials-based strategies, many inspired by pathogens, for designing mucosal vaccine platforms. Passive and active technologies are discussed, along with the microbial processes that they seek to mimic.

Graphical abstract: Expanding opportunities to engineer mucosal vaccination with biomaterials

Article information

Article type
Review Article
Submitted
17 okt 2022
Accepted
20 dek 2022
First published
30 yan 2023

Biomater. Sci., 2023,11, 1625-1647

Expanding opportunities to engineer mucosal vaccination with biomaterials

H. Freire Haddad, E. F. Roe and J. H. Collier, Biomater. Sci., 2023, 11, 1625 DOI: 10.1039/D2BM01694J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements