Issue 37, 2022

A Cu-based nanoplatform for near-infrared light amplified multi-mode prostate cancer specific therapy

Abstract

Chemodynamic therapy (CDT), as a new method for oncotherapy, can convert less reactive hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (˙OH) in the tumor microenvironment (TME) to kill tumor cells and inhibit tumor growth. However, the TME usually presents a low content of endogenous H2O2 and weak acidity, which weakens the therapeutic effect of CDT to a certain extent. Here, we developed a multifunctional nanoplatform based on Cu-doped mesoporous carbon nanospheres loaded with free radical generator 2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH) and polyacrylic acid (Cu-MNCS-AIPH@PAA). Cu-MNCS-AIPH@PAA exhibited high photothermal conversion efficiency, and could not only act as a good photothermal agent for photothermal therapy (PTT) but also trigger AIPH to produce alkyl radicals. In response to the specificity of the TME, Cu-MNCS-AIPH@PAA could generate ˙OH through a Fenton-like reaction for CDT and enhance the efficacy of CDT by a photothermal effect. The excellent anticancer efficiency by the synergistic effect of CDT, PTT and free radicals, high biocompatibility and low adverse effects of Cu-MNCS-AIPH@PAA make it an ideal nanoplatform for tumor therapy.

Graphical abstract: A Cu-based nanoplatform for near-infrared light amplified multi-mode prostate cancer specific therapy

Supplementary files

Article information

Article type
Paper
Submitted
25 may 2022
Accepted
18 iyl 2022
First published
19 iyl 2022

J. Mater. Chem. B, 2022,10, 7628-7633

A Cu-based nanoplatform for near-infrared light amplified multi-mode prostate cancer specific therapy

B. Xu, R. Niu, Y. Tang, C. Wang, L. Jin and Y. Wang, J. Mater. Chem. B, 2022, 10, 7628 DOI: 10.1039/D2TB01109C

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