Issue 37, 2022

Rational construction of polycystine-based nanoparticles for biomedical applications

Abstract

Polypeptide-based nanoparticles are one of the promising excipients of nanomedicines due to their excellent biosafety and flexible modification. Among all the types of polypeptide nanoparticles, polycystine (PCys2)-based ones draw increasing attention due to their unique properties. On the one hand, the uniformed nanogels can be easily obtained through the crosslinking of two active centers during polymerization without additional step of self-assembly. On the other hand, the Cys2-based nanoparticles always showed reduction-responsiveness owing to the inherent disulfide bond. With the development of advanced diagnostic and therapeutic technologies, the multi-functional PCys2-based nanoparticles were achieved via rational construction of the polymer structure. This review summarizes the overall development of Cys2-based polypeptide nanoparticles, especially the structural design for the generation of multi-functional nanoparticles, along with their corresponding biomedical applications.

Graphical abstract: Rational construction of polycystine-based nanoparticles for biomedical applications

Article information

Article type
Review Article
Submitted
19 mar 2022
Accepted
10 may 2022
First published
11 may 2022

J. Mater. Chem. B, 2022,10, 7173-7182

Rational construction of polycystine-based nanoparticles for biomedical applications

J. Chen, J. Yang and J. Ding, J. Mater. Chem. B, 2022, 10, 7173 DOI: 10.1039/D2TB00581F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements