Issue 21, 2022

Standard-free single magnetic bead evaluation: a stable nanoplatform for prostate disease differentiation

Abstract

Explicit interpretation of heterogeneity between prostate-specific antigen (PSA) subtypes is essential for prostate cancer differentiation during different disease courses, whereas a universal protocol with uniform criteria is still lacking across the globe. In this work, a standard-free single magnetic bead (SMB) nanoplatform utilizing metal nanoparticles with optimal diameters was proposed for prostate disease differentiation in a 134-donor model. The inaccuracy of detection in absolute quantification was diminished via evaluations of metal intensities on the single magnetic bead. The intrinsic proportion of fPSA in tPSA was successfully evaluated by direct use of the Pt to Au intensity ratio (Pt/Au ratio), exhibiting better differentiation between healthy and unhealthy, benign prostatic hyperplasia (BPH) and cancer individuals compared with solo fPSA or tPSA. We generated thresholds respectively for prostate disease differentiation, envisioning that this standard-free SMB nanoplatform would establish a standardized methodology with uniform criteria worldwide in cancer diagnosis, staging, and postoperative assessments.

Graphical abstract: Standard-free single magnetic bead evaluation: a stable nanoplatform for prostate disease differentiation

Supplementary files

Article information

Article type
Edge Article
Submitted
14 fev 2022
Accepted
28 apr 2022
First published
29 apr 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2022,13, 6270-6275

Standard-free single magnetic bead evaluation: a stable nanoplatform for prostate disease differentiation

Z. Huang, X. Xie, B. Xu, R. Liu, J. Hu and Y. Lv, Chem. Sci., 2022, 13, 6270 DOI: 10.1039/D2SC00928E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements