Issue 48, 2022

Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics

Abstract

The broad spectrum of curcumin's beneficial properties has encouraged medicinal researchers to investigate its therapeutic efficacy against diverse diseases. The clinical potential of curcumin is, however limited due to its poor pharmacodynamic/pharmacokinetic properties (such as low solubility, pH instability, poor absorption in circulation, rapid elimination from the body and photochemical degradation). 3,5-Bis(ylidene)-4-piperidone scaffolds are considered a curcumin mimic that exhibit diverse bio-properties. The current review provides a brief overview of these mimics and highlights biological activities relevant to drug development.

Graphical abstract: Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics

Article information

Article type
Review Article
Submitted
02 sen 2022
Accepted
23 okt 2022
First published
31 okt 2022
This article is Open Access
Creative Commons BY license

RSC Adv., 2022,12, 31102-31123

Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics

A. S. Girgis, P. D'Arcy, D. R. Aboshouk and M. S. Bekheit, RSC Adv., 2022, 12, 31102 DOI: 10.1039/D2RA05518J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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