Issue 48, 2022

Review on fluorinated nucleoside/non-nucleoside FDA-approved antiviral drugs

Abstract

FDA-approved antiviral agents represent an important class that has attracted attention in recent years to combat current and future threats of viral pandemics. Fluorine ameliorates the electronic, lipophilic and steric problems of drugs. Additionally, fluorine can prolong drug activity and improve metabolic stability, thereby, modifying their pharmacodynamic and pharmacokinetic character. Herein, we summarized the fluorinated FDA-approved antiviral agents, dealing with biological aspects, mechanisms of action, and synthetic pathways.

Graphical abstract: Review on fluorinated nucleoside/non-nucleoside FDA-approved antiviral drugs

Article information

Article type
Review Article
Submitted
27 avq 2022
Accepted
13 okt 2022
First published
31 okt 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 31032-31045

Review on fluorinated nucleoside/non-nucleoside FDA-approved antiviral drugs

M. M. F. Ismail and M. S. Ayoup, RSC Adv., 2022, 12, 31032 DOI: 10.1039/D2RA05370E

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements