Issue 18, 2022

The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance

Abstract

Plant-based secondary metabolites have been a major source of drug discovery and inspiration for new generations of drugs. Plants offer a wide variety of compound classes, including alkaloids, terpenes, flavonoids, and glycosides, with different molecular architectures (fused bridgehead, bi- and polycyclic, spirocyclic, polycyclic, and acyclic). The diversity, abundance, and accessibility of plant metabolites make plants an attractive source of human and animal medicine. Even though the pinene scaffold is abundant in nature and has historical use in traditional medicine, pinene and pinene-derived compounds have not been comprehensively studied for medicinal applications. This review provides insight into the utility of the pinene scaffold as a crucial building block of important natural and synthetic products and as a chiral reagent in the asymmetric synthesis of important compounds.

Graphical abstract: The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance

Article information

Article type
Review Article
Submitted
20 yan 2022
Accepted
29 mar 2022
First published
12 apr 2022
This article is Open Access
Creative Commons BY license

RSC Adv., 2022,12, 11346-11375

The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance

R. J. Nyamwihura and I. V. Ogungbe, RSC Adv., 2022, 12, 11346 DOI: 10.1039/D2RA00423B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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