Issue 7, 2022

Modulating catalytic activity of a modified flavin analogue via judicially positioned metal ion toward aerobic sulphoxidation

Abstract

This manuscript describes the synthesis, spectroscopic and crystallographic characterization of a cadmium complex of 10-propoylisoalloxazine-7-carboxylic acid (Flc-Cd). Catalytic activity of Flc-Cd towards aerobic sulphoxidation reaction was investigated in the presence of L-ascorbic acid as the reducing agent. Notably the neutral un-metalated flavin analogue did not show any significant catalytic activity. The design strategy for Flc provides a close proximity of the metal centre to the flavin core without compromising the catalytic site thereby assisting the product formation when compared to unmetallated Flc. Minor enantioselectivity is also observed in cases where unsymmetrical sulphides were used; indicative of the possible involvement of chiral L-ascorbic acid in the intermediate formation.

Graphical abstract: Modulating catalytic activity of a modified flavin analogue via judicially positioned metal ion toward aerobic sulphoxidation

Supplementary files

Article information

Article type
Paper
Submitted
31 avq 2021
Accepted
15 noy 2021
First published
01 fev 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 3990-3995

Modulating catalytic activity of a modified flavin analogue via judicially positioned metal ion toward aerobic sulphoxidation

M. S. S. V. Mouli and A. K. Mishra, RSC Adv., 2022, 12, 3990 DOI: 10.1039/D1RA06558K

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