Issue 14, 2022

Partial reductions of carboxylic acids and their derivatives to aldehydes

Abstract

The one-pot reductive synthesis of aldehydes from carboxylic acids and their derivatives without the formation of alkanol intermediates, in a redox-economical fashion, is synthetically very intriguing yet practically very challenging. Recent advances in partial reductions of carboxylic acids, acyl halides, amides, esters, nitriles, acyl hydrazides, and miscellaneous materials are reviewed. The improved protocols based on modern techniques and concepts are highlighted.

Graphical abstract: Partial reductions of carboxylic acids and their derivatives to aldehydes

Article information

Article type
Review Article
Submitted
09 may 2022
Accepted
02 iyn 2022
First published
07 iyn 2022

Org. Chem. Front., 2022,9, 3908-3931

Partial reductions of carboxylic acids and their derivatives to aldehydes

Z. Yang, Org. Chem. Front., 2022, 9, 3908 DOI: 10.1039/D2QO00748G

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