Issue 15, 2022

Formal total synthesis of dankasterone B

Abstract

An efficient and enantioselective route toward an architecturally unusual ergostane-type steroid, dankasterone B, is presented. The cis-decalin skeleton of the steroid was established by an intramolecular metal-catalyzed hydrogen atom transfer (MHAT) reaction. A radical rearrangement was used to construct the 13(14 → 8)abeo-ergostane skeleton.

Graphical abstract: Formal total synthesis of dankasterone B

Supplementary files

Article information

Article type
Research Article
Submitted
22 fev 2022
Accepted
07 iyn 2022
First published
10 iyn 2022

Org. Chem. Front., 2022,9, 3961-3965

Formal total synthesis of dankasterone B

S. Deng, H. Xu, H. Jiang and Z. Ma, Org. Chem. Front., 2022, 9, 3961 DOI: 10.1039/D2QO00299J

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