Issue 41, 2022

Heterojunction MnO2-nanosheet-decorated Ag nanowires with enhanced oxidase-like activity for the sensitive dual-mode detection of glutathione

Abstract

The biocatalytic design of nanomaterials with enzyme-like activity is considered a reliable and promising toolkit for the generation of diagnostic agents in complex biological microenvironments. However, the preparation of nanomaterials while maintaining a high catalytic activity in tumor cells (pH 6.0–6.5) poses a prominent challenge. Herein, we constructed a biomimetic enzyme-trigged dual-mode system with colorimetry at 652 nm and photothermal biosensors to detect glutathione based on hollow MnO2-nanosheet-decorated Ag nanowires (Ag@MnO2) as an oxidase-like nanozyme. As expected, Ag@MnO2 catalyzed the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the absence of H2O2, leading to a blue-colored oxidized TMB (oxTMB) that displayed oxidase-like activity in pH 6.0. Interestingly, the portable dual-mode colorimetry and photothermal method for GSH was developed based on the redox reaction between GSH and oxTMB. This detection method exhibited a wide linear range of 0.1–55 μM for GSH with a low detection limit of 0.08 μM. This work highlights a new insight into nanotechnology by taking advantage of biomimetic design in biological analysis.

Graphical abstract: Heterojunction MnO2-nanosheet-decorated Ag nanowires with enhanced oxidase-like activity for the sensitive dual-mode detection of glutathione

Supplementary files

Article information

Article type
Paper
Submitted
05 avq 2022
Accepted
26 sen 2022
First published
26 sen 2022

Nanoscale, 2022,14, 15340-15347

Heterojunction MnO2-nanosheet-decorated Ag nanowires with enhanced oxidase-like activity for the sensitive dual-mode detection of glutathione

L. Tian, Z. Huang, W. Na, Y. Liu, S. Wang, Y. He, W. Cheng, T. Huang, Z. Li and T. Li, Nanoscale, 2022, 14, 15340 DOI: 10.1039/D2NR04294K

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