Issue 12, 2022

C60-β-cyclodextrin conjugates for enhanced nucleus delivery of doxorubicin

Abstract

We demonstrate the use of water-soluble C60-β-cyclodextrin conjugates to encapsulate and deliver doxorubicin to the cell nucleus. The behaviour of the fullerene aggregates inside cells is dictated by the functionalization of the C60 cage. While both the C60 conjugates are taken up by lysosomes upon cellular entry, only the one with a hydroxylated cage rapidly escaped the lysosome. The drug delivery system (DDS) with a hydroxylated C60 cage showed significantly enhanced doxorubicin delivery to the cell nucleus, whereas the DDS with a hydrophobic C60 cage was trapped in the lysosome for a longer time and showed significantly reduced doxorubicin delivery to the nucleus. This study opens new paths towards advanced fullerene-based DDSs for small molecule drugs.

Graphical abstract: C60-β-cyclodextrin conjugates for enhanced nucleus delivery of doxorubicin

Supplementary files

Article information

Article type
Communication
Submitted
21 okt 2021
Accepted
26 fev 2022
First published
28 fev 2022

Nanoscale, 2022,14, 4456-4462

C60-β-cyclodextrin conjugates for enhanced nucleus delivery of doxorubicin

R. Biswas, S. Yang, R. A. Crichton, P. Adly-Gendi, T. K. Chen, W. P. Kopcha, Z. Shi and J. Zhang, Nanoscale, 2022, 14, 4456 DOI: 10.1039/D2NR00777K

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