Issue 9, 2022

Strategies for interface issues and challenges of neural electrodes

Abstract

Neural electrodes, as a bridge for bidirectional communication between the body and external devices, are crucial means for detecting and controlling nerve activity. The electrodes play a vital role in monitoring the state of neural systems or influencing it to treat disease or restore functions. To achieve high-resolution, safe and long-term stable nerve recording and stimulation, a neural electrode with excellent electrochemical performance (e.g., impedance, charge storage capacity, charge injection limit), and good biocompatibility and stability is required. Here, the charge transfer process in the tissues, the electrode–tissue interfaces and the electrode materials are discussed respectively. Subsequently, the latest research methods and strategies for improving the electrochemical performance and biocompatibility of neural electrodes are reviewed. Finally, the challenges in the development of neural electrodes are proposed. It is expected that the development of neural electrodes will offer new opportunities for the evolution of neural prosthesis, bioelectronic medicine, brain science, and so on.

Graphical abstract: Strategies for interface issues and challenges of neural electrodes

Supplementary files

Article information

Article type
Review Article
Submitted
01 noy 2021
Accepted
22 yan 2022
First published
25 yan 2022

Nanoscale, 2022,14, 3346-3366

Strategies for interface issues and challenges of neural electrodes

C. Liang, Y. Liu, W. Lu, G. Tian, Q. Zhao, D. Yang, J. Sun and D. Qi, Nanoscale, 2022, 14, 3346 DOI: 10.1039/D1NR07226A

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