Issue 11, 2022

Eco design for Ag-based solutions against SARS-CoV-2 and E. coli

Abstract

For the first time, we exploited the antiviral and antibacterial properties of Ag NPs stabilised by quaternized hydroxyethyl cellulose (Ag-HEC) against SARS-CoV-2 and Escherichia coli through an eco-friendly process at room temperature in three different environments: 1) water, where Ag was dispersed as a nanosol, 2) textiles, where Ag was applied as a coating, and 3) hydrogel where Ag is embedded. The antiviral performance of Ag-HEC nanosols was quantified through the selectivity index (SI), defined as the ratio between 50% cytotoxic and inhibitory concentration, in order to evaluate the ability to be active in a concentration range below the cytotoxicity value. The collected results pointed out an actual enhanced risk/benefit profile of Ag-HEC NPs with respect to chloroquine, with an SI of 22.2 and 8.4, respectively. Antibacterial and antiviral activities of Ag-HEC NPs immobilized on textiles or mucosa-like hydrogels were also assessed and their efficacy in potential application as protective clothing or nasal molecular masks was verified. This work demonstrated that a modern, safe and sustainable design allows traditional colloidal silver-based technologies to be efficiently exploited for a broad spectrum of antimicrobial solutions against bacterial and viral infections.

Graphical abstract: Eco design for Ag-based solutions against SARS-CoV-2 and E. coli

Supplementary files

Article information

Article type
Paper
Submitted
26 fev 2022
Accepted
12 may 2022
First published
17 okt 2022
This article is Open Access
Creative Commons BY-NC license

Environ. Sci.: Nano, 2022,9, 4295-4304

Eco design for Ag-based solutions against SARS-CoV-2 and E. coli

A. L. Costa, M. Blosi, A. Brigliadori, I. Zanoni, S. Ortelli, F. C. Simeone, S. Delbue, S. D'Alessandro, S. Parapini, C. Vineis, A. Varesano, M. S. Toprak, B. Hamawandi and D. Gardini, Environ. Sci.: Nano, 2022, 9, 4295 DOI: 10.1039/D2EN00178K

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