Issue 39, 2022

Controlled isolation and stabilisation of pure metastable carbamazepine form IV by droplet-confinement via a continuous manufacturing route

Abstract

This study outlines a systematic approach to control the polymorphism of carbamazepine (CBZ) and isolate the metastable polymorph CBZ form IV as a function of droplet size using spray drying as a continuous method of manufacture. In this controlled process, CBZ molecules were confined within spray dried droplets of specific size during the nucleation process to investigate the effect of confinement space on the polymorphic outcome.

Graphical abstract: Controlled isolation and stabilisation of pure metastable carbamazepine form IV by droplet-confinement via a continuous manufacturing route

Supplementary files

Article information

Article type
Communication
Submitted
28 iyl 2022
Accepted
12 sen 2022
First published
14 sen 2022
This article is Open Access
Creative Commons BY-NC license

CrystEngComm, 2022,24, 6825-6829

Controlled isolation and stabilisation of pure metastable carbamazepine form IV by droplet-confinement via a continuous manufacturing route

A. Parkes, A. Ziaee, G. Walker and E. O'Reilly, CrystEngComm, 2022, 24, 6825 DOI: 10.1039/D2CE01041K

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