Issue 5, 2022

A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy

Abstract

A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. These nanoparticles can be taken up readily by cancer cells and localised predominately in lysosomes where they disassemble gradually, leading to activation in fluorescence emission and, photocytotoxicity, showing IC50 values of as low as 1.2 μM.

Graphical abstract: A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
23 okt 2021
Accepted
07 dek 2021
First published
07 dek 2021

Chem. Commun., 2022,58, 669-672

A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy

N. M. Casellas, G. Dai, E. Y. Xue, A. Fonseca, D. K. P. Ng, M. García-Iglesias and T. Torres, Chem. Commun., 2022, 58, 669 DOI: 10.1039/D1CC05977G

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