Issue 17, 2022

An aza-BODIPY-based NIR-II luminogen enables efficient phototheranostics

Abstract

The fabrication of a high-performance second near-infrared (NIR-II) biological window fluorophore is in urgent need for precise diagnosis and treatment of cancer. Nevertheless, the construction of phototherapeutic agents in the NIR-II region with excellent imaging performance and minimal side effects remains a big challenge due to the limited availability of core fluorophore candidates. In this study, a new NIR-II fluorescent probe, CB1, which is an aza-BODIPY core conjugated with bulky donors, was designed and synthesized. CB1 was further encapsulated in DSPE-PEG2000 to impart water solubility, which shows brighter NIR-II fluorescence and higher photostability than the clinically used indocyanine green (ICG). CB1 nanoparticles show deep tissue penetration and high imaging contrast in vivo. In addition, molecular conformation enables CB1 nanoparticles to exhibit good photothermal properties. Both in vitro and in vivo assessments confirm that CB1 nanoparticles could be utilized as distinguished theranostic agents for NIR-II fluorescence imaging and tumor growth inhibition with negligible side effects. Collectively, this work provides a promising approach for constructing a new platform for cancer diagnosis and therapy.

Graphical abstract: An aza-BODIPY-based NIR-II luminogen enables efficient phototheranostics

Supplementary files

Article information

Article type
Paper
Submitted
29 apr 2022
Accepted
28 iyn 2022
First published
08 iyl 2022

Biomater. Sci., 2022,10, 4815-4821

An aza-BODIPY-based NIR-II luminogen enables efficient phototheranostics

N. Yang, S. Song, C. Liu, J. Ren, X. Wang, S. Zhu and C. Yu, Biomater. Sci., 2022, 10, 4815 DOI: 10.1039/D2BM00670G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements