Issue 44, 2022

Surface charge modulation enhanced high stability of gold oxidation intermediates for electrochemical glucose sensors

Abstract

Rapid and accurate blood glucose detection is significant for diagnosing and treating diabetes. Herein, ultra-low-content gold nanoparticles were loaded on different metal foams and applied to electrochemical enzyme-free glucose sensors via simple displacement reactions. The structures and properties of the produced catalysts were determined by various characterization methods. The performance of the glucose sensor was examined in relation to the interactions between three different metal substrates and gold. The one with the best performance is the sample of gold nanoparticles grown on copper foam (Au300 Cu Foam). It has the advantage of a porous three-dimensional network, a large electroactive surface area, and the high catalytic activity of gold. The combination of Cu and Au increased the valence state of Au, thus favoring the catalytic activity for glucose oxidation. Cyclic voltammetry and chronoamperometry measurements revealed that Au is responsible for the electrocatalytic oxidation of glucose. The sensitivity of Au300 Cu Foam was found to be 10 839 μA mM−1 cm−2 in the linear range of 0.00596–0.0566 mM, with a detection limit (LOD) of 0.223 μM, and 2–3 s response time at 0.4 V vs. Ag/AgCl. The Au300 Cu Foam glucose sensor also offered outstanding stability and anti-interference performance. The prepared Au300 Cu Foam electrode was also successfully applied to detect different levels of glucose in human body fluids, such as saliva. These characteristics make Au300 Cu Foam promising for non-invasive glucose detection.

Graphical abstract: Surface charge modulation enhanced high stability of gold oxidation intermediates for electrochemical glucose sensors

Supplementary files

Article information

Article type
Paper
Submitted
26 avq 2022
Accepted
09 okt 2022
First published
10 okt 2022

Anal. Methods, 2022,14, 4474-4484

Surface charge modulation enhanced high stability of gold oxidation intermediates for electrochemical glucose sensors

Q. Yang, F. Sun, X. Wang, J. Luo, S. Wang, C. Jia, Y. Pan, J. Zhang and Y. Zhou, Anal. Methods, 2022, 14, 4474 DOI: 10.1039/D2AY01375D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements