Issue 10, 2021

New directions of activity-based sensing for in vivo NIR imaging

Abstract

In vivo imaging is a powerful approach to study biological processes. Beyond cellular methods, in vivo studies allow for biological stimuli (small molecules or proteins) to be studied in their native environment. This has the potential to aid in the discovery of new biology and guide the development of diagnostics and therapies for diseases. To ensure selectivity and an observable readout, the probe development field is shifting towards activity-based sensing (ABS) approaches and near-infrared (NIR) imaging modalities. This perspective will highlight recent in vivo ABS applications that utilize NIR imaging platforms.

Graphical abstract: New directions of activity-based sensing for in vivo NIR imaging

Article information

Article type
Perspective
Submitted
02 iyn 2020
Accepted
28 iyn 2020
First published
03 iyl 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 3393-3405

New directions of activity-based sensing for in vivo NIR imaging

A. K. East, M. Y. Lucero and J. Chan, Chem. Sci., 2021, 12, 3393 DOI: 10.1039/D0SC03096A

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