Issue 45, 2021

The role of biocatalysis in the asymmetric synthesis of alkaloids – an update

Abstract

Alkaloids are a group of natural products with interesting pharmacological properties and a long history of medicinal application. Their complex molecular structures have fascinated chemists for decades, and their total synthesis still poses a considerable challenge. In a previous review, we have illustrated how biocatalysis can make valuable contributions to the asymmetric synthesis of alkaloids. The chemo-enzymatic strategies discussed therein have been further explored and improved in recent years, and advances in amine biocatalysis have vastly expanded the opportunities for incorporating enzymes into synthetic routes towards these important natural products. The present review summarises modern developments in chemo-enzymatic alkaloid synthesis since 2013, in which the biocatalytic transformations continue to take an increasingly ‘central’ role.

Graphical abstract: The role of biocatalysis in the asymmetric synthesis of alkaloids – an update

Supplementary files

Article information

Article type
Review Article
Submitted
29 may 2021
Accepted
30 iyl 2021
First published
20 avq 2021
This article is Open Access
Creative Commons BY license

RSC Adv., 2021,11, 28223-28270

The role of biocatalysis in the asymmetric synthesis of alkaloids – an update

E. Cigan, B. Eggbauer, J. H. Schrittwieser and W. Kroutil, RSC Adv., 2021, 11, 28223 DOI: 10.1039/D1RA04181A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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