Issue 1, 2021

Recent trends in the direct oxyphosphorylation of C–C multiple bonds

Abstract

Due to the wide importance of β-phosphorylated ketones as key building-blocks in the fabrication of various pharmaceutically active organophosphorus compounds, finding new and truly efficient methods for their preparation from simple, low-cost and ubiquitous feedstock materials within a single click is an interesting subject in organic synthesis. Recently, oxyfunctionalization of carbon–carbon multiple bonds has arisen as a straightforward and versatile tool for the synthesis of complex organic molecules from the simple and easily accessible alkenes/alkynes via a single operation. In this context, oxyphosphorylation of alkenes/alkynes with P(O)–H compounds has attracted considerable attention as a unique procedure for the construction of β-phosphorylated ketones. In this review, we outline the recent advances and developments in this fast-growing research field with particular emphasis on the mechanistic aspects of reaction.

Graphical abstract: Recent trends in the direct oxyphosphorylation of C–C multiple bonds

Article information

Article type
Review Article
Submitted
21 sen 2020
Accepted
04 dek 2020
First published
23 dek 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 470-483

Recent trends in the direct oxyphosphorylation of C–C multiple bonds

A. Bakhtiary, M. R. Poor Heravi, A. Hassanpour, I. Amini and E. Vessally, RSC Adv., 2021, 11, 470 DOI: 10.1039/D0RA08074H

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