Issue 17, 2021

Facile and practical hydrodehalogenations of organic halides enabled by calcium hydride and palladium chloride

Abstract

Herein, a convenient hydrodehalogenation method was described by employing less-explored calcium hydride as the reductant. A wide range of organic halides such as aromatic bromides, aromatic chlorides, aromatic triflates, aliphatic bromides and aliphatic chlorides were efficiently and selectively reduced to obtain the corresponding hydrocarbons. More importantly, monodehalogenation of trihalomethyl compounds in THF could provide various useful dihalomethyl products.

Graphical abstract: Facile and practical hydrodehalogenations of organic halides enabled by calcium hydride and palladium chloride

Supplementary files

Article information

Article type
Research Article
Submitted
21 may 2021
Accepted
29 iyn 2021
First published
29 iyn 2021

Org. Chem. Front., 2021,8, 4685-4692

Facile and practical hydrodehalogenations of organic halides enabled by calcium hydride and palladium chloride

J. Gui, X. Cai, L. Chen, Y. Zhou, W. Zhu, Y. Jiang, M. Hu, X. Chen, Y. Hu and S. Zhang, Org. Chem. Front., 2021, 8, 4685 DOI: 10.1039/D1QO00758K

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