Issue 44, 2021

Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine

Abstract

Judicious substrate design allows interruption of the classical Bischler–Napieralski reaction, providing access to a range of diversely substituted tetracyclic spiroindolines. These complex polycyclic scaffolds are valuable building blocks for the construction of indole alkaloids, as showcased in a concise total synthesis of (±)-akuammicine.

Graphical abstract: Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine

Supplementary files

Article information

Article type
Communication
Submitted
07 okt 2021
Accepted
27 okt 2021
First published
27 okt 2021
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2021,19, 9641-9644

Synthesis of tetracyclic spiroindolines by an interrupted Bischler–Napieralski reaction: total synthesis of akuammicine

M. Faltracco and E. Ruijter, Org. Biomol. Chem., 2021, 19, 9641 DOI: 10.1039/D1OB01966J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements