Issue 1, 2021

Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds

Abstract

Covering: up to the beginning of 2020

Many natural substances have been transformed again and again with regard to their pharmaceutical-medical potential, including new members of a growing class of natural products, the flavaglines. Important representatives are rocaglamide and silvestrol, isolated from the Aglaia species, which are highlighted here. These products started as potential anti-tumor agents five decades ago and have recently proved to be very promising antiviral agents, especially against RNA viruses. Today they are discussed as potential starting compounds for developing drug candidates and therapeutics.

Graphical abstract: Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds

Article information

Article type
Highlight
Submitted
14 may 2020
First published
23 iyl 2020

Nat. Prod. Rep., 2021,38, 18-23

Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds

G. Schulz, C. Victoria, A. Kirschning and E. Steinmann, Nat. Prod. Rep., 2021, 38, 18 DOI: 10.1039/D0NP00024H

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