Issue 10, 2021

Controlled covalent functionalization of a graphene-channel of a field effect transistor as an ideal platform for (bio)sensing applications

Abstract

The controlled covalent functionalization of the graphene channel of a field effect transistor, based on interdigitated gold electrodes (source and drain), via electrochemical grafting, using specifically designed aryl diazonium species is demonstrated to allow the simple fabrication of a general platform for (bio)sensing applications. The electrochemical grafting of a protected ethynylphenyl diazonium salt leads to the deposition of only a monolayer on the graphene channel. This controlled covalent functionalization of the graphene channel results in a charge mobility of the GFET of 1739 ± 376 cm2 V−1 s−1 and 1698 ± 536 cm2 V−1 s−1 for the holes and electrons, respectively, allowing their utilization as (bio)sensors. After deprotection, a dense and compact ethynylphenyl monolayer is obtained and allows the immobilization of a wide range of (bio)molecules by a “click” chemistry coupling reaction (Huisgen 1,3-dipolar cycloaddition). This finding opens promising options for graphene-based (bio)sensing applications.

Graphical abstract: Controlled covalent functionalization of a graphene-channel of a field effect transistor as an ideal platform for (bio)sensing applications

Supplementary files

Article information

Article type
Communication
Submitted
08 iyl 2021
Accepted
10 avq 2021
First published
10 avq 2021

Nanoscale Horiz., 2021,6, 819-829

Controlled covalent functionalization of a graphene-channel of a field effect transistor as an ideal platform for (bio)sensing applications

V. Mishyn, T. Rodrigues, Y. R. Leroux, P. Aspermair, H. Happy, J. Bintinger, C. Kleber, R. Boukherroub, W. Knoll and S. Szunerits, Nanoscale Horiz., 2021, 6, 819 DOI: 10.1039/D1NH00355K

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