Issue 18, 2021

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Abstract

The eye is a complex structure with a variety of anatomical barriers and clearance mechanisms, so the provision of safe and effective ophthalmic drug delivery technology is a major challenge. In the past few decades, a number of reports have shown that nano-delivery platforms based on polymeric micelles are of great interest, because of their hydrophobic core that encapsulates lipid-soluble drugs and small size with high penetration, allowing long-term drug retention and posterior penetration in the eye. Furthermore, as an ocular delivery platform, polymeric micelles not only cover the single micellar drug delivery system formed by poloxamer, chitosan or other polymers, but also include composite drug delivery systems like micelle-encapsulated hydrogels and micelle-embedded contact lenses. In this review, a number of ophthalmic micelles that have emerged in the last three years will be systematically reviewed, with a summary of and discussion on their unique advantages or unique drug delivery performance. Last but not least, the current challenges of polymeric micelle formulations in potential clinical ophthalmic therapeutic applications will also be proposed, which might be helpful for future design of ocular drug delivery formulations.

Graphical abstract: Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Article information

Article type
Review Article
Submitted
30 iyl 2021
Accepted
08 avq 2021
First published
10 avq 2021
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 5240-5254

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Z. Li, M. Liu, L. Ke, L. Wang, C. Wu, C. Li, Z. Li and Y. Wu, Nanoscale Adv., 2021, 3, 5240 DOI: 10.1039/D1NA00596K

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