Issue 19, 2021

Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects

Abstract

Timely and accurate diagnosis of breast cancer is essential for efficient treatment and the best possible survival rates. Biosensors have emerged as a smart diagnostic platform for the detection of biomarkers specific to the onset, recurrence, and therapeutic drug monitoring of breast cancer. There have been exciting recent developments, including significant improvements in the validation, sensitivity, specificity, and integration of sample processing steps to develop point-of-care (POC) integrated micro-total analysis systems for clinical settings. The present review highlights various biosensing modalities (electrical, optical, piezoelectric, mass, and acoustic sensing). It provides deep insights into their design principles, signal amplification strategies, and comparative performance analysis. Finally, this review emphasizes the status of existing integrated micro-total analysis systems (μ-TAS) for personalized breast cancer therapeutics and associated challenges and outlines the approach required to realize their successful translation into clinical settings.

Graphical abstract: Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects

Article information

Article type
Review Article
Submitted
19 iyn 2021
Accepted
12 avq 2021
First published
12 avq 2021
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 5542-5564

Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects

A. Joshi, A. Vishnu G. K., T. Sakorikar, A. M. Kamal, J. S. Vaidya and H. J. Pandya, Nanoscale Adv., 2021, 3, 5542 DOI: 10.1039/D1NA00453K

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