Issue 14, 2021

Reversible facile single-crystal-to-single-crystal polymorphic transition accompanied by unit cell volume expansion and twinning

Abstract

Reversible single-crystal-to-single-crystal phase transformation between two enantiotropic polymorphs of a pharmaceutical salt, diphenhydramine citrate, in both directions is accompanied by a transient expansion in the unit cell, allowing rotation of phenyl rings. Twinning of the lower symmetry polymorph facilitates the exceptional reproducibility and the lack of observable hysteresis in the phase change.

Graphical abstract: Reversible facile single-crystal-to-single-crystal polymorphic transition accompanied by unit cell volume expansion and twinning

Supplementary files

Article information

Article type
Communication
Submitted
13 yan 2021
Accepted
17 mar 2021
First published
22 mar 2021

CrystEngComm, 2021,23, 2648-2653

Reversible facile single-crystal-to-single-crystal polymorphic transition accompanied by unit cell volume expansion and twinning

K. Wang, C. Wang, M. K. Mishra, V. G. Young and C. C. Sun, CrystEngComm, 2021, 23, 2648 DOI: 10.1039/D1CE00055A

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