Issue 85, 2021

Photochemistry and in vitro anticancer activity of Pt(iv)Re(i) conjugates

Abstract

The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer.

Graphical abstract: Photochemistry and in vitro anticancer activity of Pt(iv)Re(i) conjugates

Supplementary files

Article information

Article type
Communication
Submitted
21 avq 2021
Accepted
01 okt 2021
First published
08 okt 2021

Chem. Commun., 2021,57, 11189-11192

Author version available

Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates

Z. Huang, A. P. King, J. Lovett, B. Lai, J. J. Woods, H. H. Harris and J. J. Wilson, Chem. Commun., 2021, 57, 11189 DOI: 10.1039/D1CC04669A

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