Issue 89, 2021

Sterically controlled C–H alkenylation of pyrroles and thiophenes

Abstract

Pd-catalyzed C–H alkenylations targeting the least hindered position of N-alkyl pyrroles and 3-substituted thiophenes, as opposed to electronically controlled approaches, are developed. The steric demand and stable bidentate binding mode of the pyrazolonaphthyridine ligand are key to the success of these sterically controlled alkenylations using oxygen as an oxidant.

Graphical abstract: Sterically controlled C–H alkenylation of pyrroles and thiophenes

Supplementary files

Article information

Article type
Communication
Submitted
10 avq 2021
Accepted
14 okt 2021
First published
14 okt 2021

Chem. Commun., 2021,57, 11791-11794

Sterically controlled C–H alkenylation of pyrroles and thiophenes

E. Kang, J. E. Jeon, S. Jeong, H. T. Kim and J. M. Joo, Chem. Commun., 2021, 57, 11791 DOI: 10.1039/D1CC04378A

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