Issue 42, 2020

A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy

Abstract

To enhance the efficacy of nanoparticle-based cancer therapy with reduced side effects and promote its clinical translation, a biocompatible nanocomposite based on mesoporous silica-coated gold nanorods (AuNR@MSN) for triple tumor therapy is reported in this study. The gold core served as a hyperthermia agent, while the MSN shell acted as a reservoir of chemotherapeutics owing to its excellent loading capacity. Cytochrome c with the apoptosis inducing function was anchored on the surface of AuNR@MSN to prevent drug leakage through redox-responsive disulfide bonds. The successful construction of a nanocomposite was confirmed by characterization of the physicochemical properties. In vitro and in vivo studies demonstrated that the nanocomposite displayed an optimizing anti-tumor effect with a synergistic strategy of excellent photothermal therapy, chemotherapy and protein therapy. Therefore, this cooperative strategy paves the way for high-efficiency oncotherapy with reduced side effects.

Graphical abstract: A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy

Supplementary files

Article information

Article type
Paper
Submitted
10 iyl 2020
Accepted
07 sen 2020
First published
16 sen 2020

J. Mater. Chem. B, 2020,8, 9686-9696

A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy

G. Liu, H. Liang, Y. He, L. Lu, L. Wang, P. Liu and K. Cai, J. Mater. Chem. B, 2020, 8, 9686 DOI: 10.1039/D0TB01707H

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