Issue 30, 2020

Nickel-catalyzed three-component olefin reductive dicarbofunctionalization to access alkylborates

Abstract

We report a three-component olefin reductive dicarbofunctionalization for constructing alkylborates, specifically, nickel-catalyzed reductive dialkylation and alkylarylation of vinyl boronates with a variety of alkyl bromides and aryl iodides. This reaction exhibits good coupling efficiency and excellent functional group compatibility, providing convenient access to the late-stage modification of complex natural products and drug molecules. Combined with alkylborate transformations, this reaction could also find applications in the modular and convergent synthesis of complex compounds.

Graphical abstract: Nickel-catalyzed three-component olefin reductive dicarbofunctionalization to access alkylborates

Supplementary files

Article information

Article type
Edge Article
Submitted
12 apr 2020
Accepted
03 iyl 2020
First published
08 iyl 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2020,11, 7950-7956

Nickel-catalyzed three-component olefin reductive dicarbofunctionalization to access alkylborates

X. Wang, X. Lu, S. He and Y. Fu, Chem. Sci., 2020, 11, 7950 DOI: 10.1039/D0SC02054K

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