Issue 22, 2020

Recent advances in N-heterocyclic carbene-based radical catalysis

Abstract

In nature, a number of enzymes use thiamine diphosphate as a coenzyme to catalyze the pyruvate decarboxylation. The resultant enamine, a so-called “Breslow intermediate,” is known to perform single electron transfer to various electron acceptors. Inspired by this enzymatic catalysis, N-heterocyclic carbene (NHC)-catalyzed radical reactions have been developed. This minireview highlights the recent progress and developments in NHC-based radical catalysis. This minireview is categorized according to the reaction types; oxidation type reaction and carbon–carbon bond formation through single electron transfer/radical–radical coupling.

Graphical abstract: Recent advances in N-heterocyclic carbene-based radical catalysis

Article information

Article type
Minireview
Submitted
16 mar 2020
Accepted
10 may 2020
First published
11 may 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2020,11, 5630-5636

Recent advances in N-heterocyclic carbene-based radical catalysis

T. Ishii, K. Nagao and H. Ohmiya, Chem. Sci., 2020, 11, 5630 DOI: 10.1039/D0SC01538E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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