Issue 67, 2020

The oxazolomycin family: a review of current knowledge

Abstract

Oxazolomycin A and neooxazolomycin were firstly isolated in 1985 by the group of Uemura et al. from the Streptomyces sp. bacteria. To date, there have been reported 15 different natural compounds commonly classified as part of the oxazolomycin family. All oxazolomycin compounds possess extraordinary structures and they represent a synthetic challenge. Such molecules are additionally known for their wide range of biological activity including antibacterial, antiviral and cytotoxic effects. The present review summarizes the structural elucidation and classification of oxazolomycin compounds, their biosynthesis and biological activity. It is further focused on the total syntheses of oxazolomycins and one formal synthesis reported to date.

Graphical abstract: The oxazolomycin family: a review of current knowledge

Article information

Article type
Review Article
Submitted
01 okt 2020
Accepted
25 okt 2020
First published
09 noy 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 40745-40794

The oxazolomycin family: a review of current knowledge

P. Oleksak, J. Gonda, E. Nepovimova, K. Kuca and K. Musilek, RSC Adv., 2020, 10, 40745 DOI: 10.1039/D0RA08396H

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements