Issue 45, 2020

Xanthan gum derivatives: review of synthesis, properties and diverse applications

Abstract

Natural polysaccharides are well known for their biocompatibility, non-toxicity and biodegradability. These properties are also inherent to xanthan gum (XG), a microbial polysaccharide. This biomaterial has been extensively investigated as matrices for tablets, nanoparticles, microparticles, hydrogels, buccal/transdermal patches, tissue engineering scaffolds with different degrees of success. However, the native XG has its own limitations with regards to its susceptibility to microbial contamination, unusable viscosity, poor thermal and mechanical stability, and inadequate water solubility. Chemical modification can circumvent these limitations and tailor the properties of virgin XG to fulfill the unmet needs of drug delivery, tissue engineering, oil drilling and other applications. This review illustrates the process of chemical modification and/crosslinking of XG via etherification, esterification, acetalation, amidation, and oxidation. This review further describes the tailor-made properties of novel XG derivatives and their potential application in diverse fields. The physicomechanical modification and its impact on the properties of XG are also discussed. Overall, the recent developments on XG derivatives are very promising to progress further with polysaccharide research.

Graphical abstract: Xanthan gum derivatives: review of synthesis, properties and diverse applications

Article information

Article type
Review Article
Submitted
16 may 2020
Accepted
13 iyl 2020
First published
21 iyl 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 27103-27136

Xanthan gum derivatives: review of synthesis, properties and diverse applications

J. Patel, B. Maji, N. S. H. N. Moorthy and S. Maiti, RSC Adv., 2020, 10, 27103 DOI: 10.1039/D0RA04366D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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