Issue 46, 2020

Electrochemically controlled cleavage of imine bonds on a graphene platform: towards new electro-responsive hybrids for drug release

Abstract

Graphene-based materials are particularly suitable platforms for the development of new systems able to release drugs upon the application of controlled electrochemical stimuli. Herein, we report a new electro-responsive graphene carrier functionalised with aldehydes (as drug models) through imine-based linkers. We explore a new type of drug loading/release combination based on the formation of a covalent bond and its cleavage upon electrolysis. The new graphene–drug model hybrid is stable under physiological conditions and displays a fast drug release upon the application of low voltages.

Graphical abstract: Electrochemically controlled cleavage of imine bonds on a graphene platform: towards new electro-responsive hybrids for drug release

Supplementary files

Article information

Article type
Paper
Submitted
28 may 2020
Accepted
04 avq 2020
First published
25 noy 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2020,12, 23824-23830

Electrochemically controlled cleavage of imine bonds on a graphene platform: towards new electro-responsive hybrids for drug release

H. Hou, L. Cardo, D. Mancino, B. Arnaiz, A. Criado and M. Prato, Nanoscale, 2020, 12, 23824 DOI: 10.1039/D0NR04102E

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