Issue 15, 2020

A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

Abstract

A fluorescent, naphthalimide-based, NADH mimic has been synthesised as a reversible, biocompatible, “on–off” probe for the detection of changes in intracellular redox environment (both oxidation and reduction). Interconversion was confirmed by means of electrochemistry and also 1H NMR, UV-vis and fluorescence spectroscopy. The reversibility was also successfully detected in A549 cells under simulated redox stress.

Graphical abstract: A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

Supplementary files

Article information

Article type
Communication
Submitted
16 dek 2019
Accepted
22 yan 2020
First published
22 yan 2020

Chem. Commun., 2020,56, 2240-2243

A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state

H. Sharma, N. K. Tan, N. Trinh, J. H. Yeo, E. J. New and F. M. Pfeffer, Chem. Commun., 2020, 56, 2240 DOI: 10.1039/C9CC09748A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements